Arthritis Life

Rheumer Has It: The Science of Exercise & RA

Episode Summary

In this episode, Cheryl and Eileen sit down with Dr. Brian Andonian of Duke University, whose research on exercise, aging, and rheumatic disease captured their attention at the 2025 ACR Conference. He sheds light on the powerful ways exercise influences the immune system, inflammation, cardiovascular health, and even cellular aging in rheumatoid arthritis, far beyond the outdated notion that RA is “just a joint disease.”

Episode Notes

Together, they break down common myths about fragility, rest, and “wear and tear,” while explaining why tailored exercise programs are not only safe but essential. Dr. Andonian also offers practical guidance for managing fatigue, using slow progression, and finding trustworthy exercise resources. This episode is a must-listen for anyone looking to understand how movement can improve whole-body health with RA.

Episode at a glance:

• 1. Exercise is far more than “movement” - it directly supports immune health, slows accelerated aging, and improves disease activity in RA.
  Dr. Andonian explains how aerobic and strength training influence inflammation, cellular metabolism, and mitochondrial function in ways that go far beyond joint comfort.
• 2. RA is a whole-body immune disease, so exercise must be tailored, not avoided.
  Listeners learn why joints are actually a secondary issue in RA, why “too fragile to exercise” is a myth, and how the right mix of aerobic, strength, and mobility work can support the cardiovascular, respiratory, and immune systems.
• 3. There is no one-size-fits-all exercise plan; successful programs must be personalized.
  Dr. Andonian breaks down how arthritis type, disease location, comorbidities, and fatigue shape exercise prescriptions, and why slow progression and “exercise snacks” are essential for many patients.

Medical disclaimer: 

All content found on Arthritis Life public channels (including Rheumer Has It) was created for generalized informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

Episode Sponsors

Rheum to THRIVE, an online course and support program Cheryl created to help people with rheumatic disease go from overwhelmed, confused and alone to confident, supported and connected. See all the details and join the program or waitlist now!